Requirement of GATA-1 and p45 NF-E2 Expression in Butyric Acid-Induced Erythroid Differentiation
نویسندگان
چکیده
منابع مشابه
Requirement of GATA-1 and p45 NF-E2 expression in butyric acid-induced erythroid differentiation.
Butyric acid (BA) is known to induce overexpression of fetal hemoglobin and then erythroid differentiation. Therefore, BA is currently under clinical investigation as a potential therapy for the treatment of sickle cell disease and cancer. Nevertheless, the molecular mechanisms involved in BA-induced differentiation remain largely unknown. Previous reports have shown that BA-induced overexpress...
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Regulated expression of genes in the beta-globin cluster depends upon sequences located between 5 and 20 kb upstream of the epsilon gene, known as the locus control region (LCR). beta-Globin expression in murine erythroleukemia (MEL) cells depends on NF-E2, a transcription factor which binds to enhancer sequences in the LCR. To gain insight into the mechanism of globin gene activation by NF-E2,...
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MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differen...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1998
ISSN: 0006-291X
DOI: 10.1006/bbrc.1998.9869